Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
56 |
S |
62 |
L |
0.77 |
2 |
51 |
K |
74 |
G |
0.52 |
3 |
88 |
G |
92 |
L |
0.49 |
4 |
42 |
G |
48 |
L |
0.48 |
5 |
51 |
K |
55 |
A |
0.45 |
6 |
91 |
S |
95 |
K |
0.44 |
7 |
71 |
L |
75 |
G |
0.43 |
8 |
58 |
E |
62 |
L |
0.43 |
9 |
92 |
L |
98 |
L |
0.43 |
10 |
68 |
K |
82 |
N |
0.41 |
11 |
103 |
G |
110 |
F |
0.40 |
12 |
102 |
K |
109 |
S |
0.39 |
13 |
64 |
L |
68 |
K |
0.38 |
14 |
199 |
A |
203 |
K |
0.38 |
15 |
68 |
K |
85 |
I |
0.38 |
16 |
48 |
L |
75 |
G |
0.38 |
17 |
93 |
V |
100 |
Q |
0.38 |
18 |
87 |
L |
91 |
S |
0.37 |
19 |
23 |
A |
29 |
K |
0.37 |
20 |
181 |
K |
185 |
P |
0.36 |
21 |
182 |
A |
191 |
A |
0.36 |
22 |
70 |
A |
74 |
G |
0.36 |
23 |
51 |
K |
75 |
G |
0.36 |
24 |
204 |
A |
209 |
A |
0.35 |
25 |
101 |
T |
109 |
S |
0.35 |
26 |
103 |
G |
108 |
G |
0.35 |
27 |
201 |
K |
206 |
K |
0.35 |
28 |
194 |
P |
198 |
K |
0.35 |
29 |
199 |
A |
206 |
K |
0.34 |
30 |
147 |
K |
151 |
A |
0.34 |
31 |
203 |
K |
209 |
A |
0.34 |
32 |
28 |
P |
32 |
A |
0.34 |
33 |
166 |
A |
177 |
K |
0.33 |
34 |
198 |
K |
204 |
A |
0.33 |
35 |
70 |
A |
75 |
G |
0.33 |
36 |
203 |
K |
207 |
P |
0.33 |
37 |
196 |
K |
201 |
K |
0.33 |
38 |
100 |
Q |
110 |
F |
0.33 |
39 |
45 |
V |
85 |
I |
0.33 |
40 |
172 |
S |
176 |
P |
0.33 |
41 |
26 |
K |
30 |
K |
0.33 |
42 |
204 |
A |
208 |
K |
0.32 |
43 |
173 |
A |
177 |
K |
0.32 |
44 |
174 |
K |
179 |
V |
0.32 |
45 |
57 |
K |
62 |
L |
0.32 |
46 |
33 |
G |
38 |
R |
0.32 |
47 |
200 |
V |
207 |
P |
0.32 |
48 |
191 |
A |
202 |
P |
0.32 |
49 |
106 |
A |
110 |
F |
0.32 |
50 |
176 |
P |
182 |
A |
0.32 |
51 |
197 |
A |
203 |
K |
0.31 |
52 |
24 |
A |
32 |
A |
0.31 |
53 |
198 |
K |
203 |
K |
0.31 |
54 |
168 |
A |
173 |
A |
0.31 |
55 |
53 |
V |
112 |
L |
0.31 |
56 |
194 |
P |
199 |
A |
0.31 |
57 |
192 |
K |
198 |
K |
0.31 |
58 |
184 |
K |
188 |
A |
0.30 |
59 |
25 |
A |
31 |
A |
0.30 |
60 |
105 |
G |
109 |
S |
0.30 |
61 |
80 |
K |
84 |
R |
0.30 |
62 |
198 |
K |
210 |
A |
0.30 |
63 |
195 |
A |
199 |
A |
0.30 |
64 |
182 |
A |
198 |
K |
0.30 |
65 |
40 |
P |
50 |
T |
0.30 |
66 |
92 |
L |
101 |
T |
0.30 |
67 |
90 |
K |
100 |
Q |
0.30 |
68 |
30 |
K |
36 |
K |
0.30 |
69 |
31 |
A |
35 |
A |
0.29 |
70 |
46 |
T |
50 |
T |
0.29 |
71 |
28 |
P |
33 |
G |
0.29 |
72 |
188 |
A |
197 |
A |
0.29 |
73 |
205 |
A |
210 |
A |
0.29 |
74 |
199 |
A |
204 |
A |
0.29 |
75 |
199 |
A |
205 |
A |
0.28 |
76 |
174 |
K |
188 |
A |
0.28 |
77 |
102 |
K |
107 |
S |
0.28 |
78 |
169 |
T |
174 |
K |
0.28 |
79 |
125 |
K |
129 |
S |
0.28 |
80 |
23 |
A |
31 |
A |
0.28 |
81 |
86 |
K |
93 |
V |
0.28 |
82 |
197 |
A |
202 |
P |
0.28 |
83 |
101 |
T |
110 |
F |
0.28 |
84 |
84 |
R |
89 |
L |
0.27 |
85 |
200 |
V |
209 |
A |
0.27 |
86 |
197 |
A |
204 |
A |
0.27 |
87 |
200 |
V |
210 |
A |
0.27 |
88 |
176 |
P |
184 |
K |
0.27 |
89 |
181 |
K |
187 |
K |
0.27 |
90 |
81 |
N |
92 |
L |
0.27 |
91 |
25 |
A |
32 |
A |
0.27 |
92 |
27 |
K |
31 |
A |
0.27 |
93 |
191 |
A |
200 |
V |
0.27 |
94 |
174 |
K |
184 |
K |
0.27 |
95 |
173 |
A |
179 |
V |
0.27 |
96 |
33 |
G |
40 |
P |
0.27 |
97 |
203 |
K |
210 |
A |
0.27 |
98 |
59 |
R |
69 |
K |
0.26 |
99 |
58 |
E |
72 |
A |
0.26 |
100 |
105 |
G |
110 |
F |
0.26 |
101 |
194 |
P |
200 |
V |
0.26 |
102 |
195 |
A |
209 |
A |
0.26 |
103 |
185 |
P |
190 |
A |
0.26 |
104 |
200 |
V |
204 |
A |
0.26 |
105 |
150 |
K |
156 |
K |
0.26 |
106 |
60 |
K |
109 |
S |
0.26 |
107 |
186 |
K |
194 |
P |
0.26 |
108 |
200 |
V |
206 |
K |
0.26 |
109 |
165 |
A |
182 |
A |
0.26 |
110 |
99 |
V |
113 |
S |
0.26 |
111 |
45 |
V |
68 |
K |
0.26 |
112 |
23 |
A |
27 |
K |
0.26 |
113 |
79 |
E |
90 |
K |
0.26 |
114 |
63 |
S |
109 |
S |
0.26 |
115 |
23 |
A |
28 |
P |
0.26 |
116 |
53 |
V |
67 |
L |
0.26 |
117 |
28 |
P |
37 |
A |
0.26 |
118 |
177 |
K |
186 |
K |
0.26 |
119 |
198 |
K |
205 |
A |
0.25 |
120 |
185 |
P |
192 |
K |
0.25 |
121 |
194 |
P |
202 |
P |
0.25 |
122 |
59 |
R |
111 |
R |
0.25 |
123 |
189 |
V |
193 |
S |
0.25 |
124 |
175 |
S |
180 |
T |
0.25 |
125 |
202 |
P |
210 |
A |
0.25 |
126 |
26 |
K |
33 |
G |
0.25 |
127 |
45 |
V |
64 |
L |
0.25 |
128 |
177 |
K |
184 |
K |
0.25 |
129 |
201 |
K |
207 |
P |
0.25 |
130 |
11 |
E |
26 |
K |
0.25 |
131 |
82 |
N |
87 |
L |
0.25 |
132 |
51 |
K |
70 |
A |
0.25 |
133 |
45 |
V |
71 |
L |
0.25 |
134 |
82 |
N |
100 |
Q |
0.25 |
135 |
174 |
K |
181 |
K |
0.25 |
136 |
197 |
A |
210 |
A |
0.25 |
137 |
175 |
S |
179 |
V |
0.25 |
138 |
67 |
L |
85 |
I |
0.25 |
139 |
84 |
R |
88 |
G |
0.25 |
140 |
30 |
K |
40 |
P |
0.25 |
141 |
81 |
N |
86 |
K |
0.25 |
142 |
195 |
A |
206 |
K |
0.25 |
143 |
166 |
A |
174 |
K |
0.25 |
144 |
64 |
L |
103 |
G |
0.25 |
145 |
191 |
A |
199 |
A |
0.25 |
146 |
79 |
E |
86 |
K |
0.25 |
147 |
64 |
L |
82 |
N |
0.25 |
148 |
168 |
A |
178 |
K |
0.25 |
149 |
195 |
A |
204 |
A |
0.25 |
150 |
146 |
K |
150 |
K |
0.25 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation